High homocysteine levels are associated with cardiovascular disease and dementia. A series of studies have shown that the relationship with cardiovascular disease is not causal [1,2]. However, yet another series of randomized controlled trials have shown that reducing homocysteine levels reduces brain atrophy and cognitive decline [3,4,5], as well as risk of stroke [6] and symptom severity in schizophrenia [7,8]. Yet other studies suggest still other benefits for psychiatric disorders such as bipolar disorder [9]. This podcast explores the risks and benefits of homocysteine reduction by the use of three vitamins: B12, B6, and folate, as well as what might be the recommended dose for this purpose [10]. The potential benefits are well-established, but there is a signal for increased risk of unstable angina and non-fatal myocardial infarction in two of the major studies that have looked at the role of homocysteine reduction in cardiovascular disease [1,2]. Those at higher risk of cardiovascular disease should therefore be cautious if they decide to supplement with B12, B6, and folate to lower homocysteine levels.

Those who decide to do so can use the dose used by Cornell’s Alzheimer’s prevention expert Richard Isaacson for his patients: 800 mcg/day folic acid, 20 mg/day B6, and 500 mcg/day B12 [10].

References (PMIDs):

[1] 16450017
[2] 16531614
[3] 20838622
[4] 23690582
[5] 25877495
[6] 19228852
[7] 23467813
[8] 16412989
[9] 35386526
[10] 30446421

Find the podcast on this topic at:

Spotify: https://open.spotify.com/episode/5rZVSdKU7d2WE0CaZBroBQ?si=445135ac5a29410f

Apple Podcasts: https://podcasts.apple.com/us/podcast/the-kevin-bass-show/id1500347558#episodeGuid=http%3A%2F%2Fwww.blubrry.com%2Fdietwars%2F84513191%2Fslow-brain-aging-and-improve-brain-health-with-these-three-vitamins%2F

Youtube: https://www.youtube.com/watch?v=LcppOs0XwoE



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